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KMID : 0811720060100000324
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Korean Journal of Physiology & Pharmacology
2006 Volume.10 No. 0 p.324 ~ p.0
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ASSOCIATION OF GULTATHIONE S-TRANSFERASES (GSTM1 AND GSTT1) POLYMORPHISM OF VITILIGO IN KOREAN POPULATION
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Uhm Yoon-Kyung
Jung Kyung-Hee
Park Hae-Jeong
Kim Mi-Ja
Kim Hye-Kyung
Kim Hak-Jae
Won Hye-Jin
Hong Mee-Suk
Chung Joo-Ho
Yim Sung-Vin
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Abstract
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Vitiligo is an acquired pigmentary disorder of the skin involving melatocyte dysfunction. It has been reported that melanocyte impairment could be related to increased oxidative stress. The glutathione S-transferases (GSTs) are a group of polymorphic enzymes that are important in protection against oxidant stress. To address the possible association between oxidative stress and vitiligo susceptibly, GSTM1 (homozygous deletion vs. non-deleted) and GSTT1 (homozygous deletion vs. non-deleted) polymorphisms between vitiligo patients (n=310) and healthy controls (n=549) were analyzed by polymerase chain reaction. We observed significant association in null alleles of the GSTM1 (P<0.001, OR=2.048, 95% CI=1.529～2.743). Howerver, no significant association in GSTT1 (P=0.869, OR=1.024, 95% CI=0.775～1.353) was observed with vitiligo. GSTM1 null type was also different between vitiligo subtype (focal; P<0.001, OR=2.251, 95% CI=1.530～3.313 and generalized; P=0.001, OR=1.915, 95% CI=1.291～2.841). In combined analysis of GSTM1 and GSTT1, both null type and GSTM1/GSTT1 (－/+) group showed significant differences between controls and vitiligo patients. The results suggest that GSTM1 null type might be associated with vitiligo in Koreans.
Source: Korean J Physiol Pharmacol.2006 Oct;10(Suppl II):238
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KEYWORD
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Vitiligo, Glutathione S-transferases (GSTs), GSTT1/GSTM1
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